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PUBLICATIONS & PATENTS

• Rita De Santis, Anna Maria Anastasi, Angela Pelliccia, Antonio Rosi, Claudio Albertoni, Antonio
  Verdoliva, Fiorella Petronzelli, Valeria D’Alessio, Serenella Serani, Carlo Antonio Nuzzolo.

Chemical Linkage to Injected Tissues Is a Distinctive Property of Oxidized Avidin.
6(6):e21075 (2011)

• Verdoliva A., Rivieccio V., Rossi M.

Simplified b-amyloid peptides for safer Alzheimer Vaccines development
Human Vaccines 6(11):936-947 (2010)

• Deban L, Russo RC, Sironi M, Moalli F, Scanziani M, Zambelli V, Cuccovillo I, Bastone A, Gobbi M, Valentino S, Doni A, Garlanda C, Danese S, Salvatori G, Sassano M, Evangelista V, Rossi B, Zenaro E, Constantin G, Laudanna C, Bottazzi B, Mantovani A.

Regulation of leukocyte recruitment by the long pentraxin PTX3.
Nat Immunol. 11(4):328-34 (2010)

• Inforzato A, Baldock C, Jowitt TA, Holmes DF, Lindstedt R, Marcellini M, Rivieccio V, Briggs DC, Kadler KE, Verdoliva A, Bottazzi B, Mantovani A, Salvatori G, Day AJ.

The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2.
J. Biol. Chem. 285(23):17681-92 (2010)

• Pratesi A, Bucelli F, Mori I, Chinol M, Verdoliva A, Paganelli G, Rivieccio V, Gariboldi L, Ginanneschi M.

Biotin Derivatives Carrying Two Chelating DOTA Units. Synthesis, in Vitro Evaluation of Biotinidases Resistance, Avidin Binding, and Radiolabeling Tests
J Med Chem. 53 (1), 432-440 (2010)

• Verdoliva A., Bellofiore P., Rivieccio V., Catello S., Colombo M., Albertoni C., Rosi A., Leoni B., Anastasi A.M., De Santis R.

Biochemical and biological characterization of a new oxidized avidin with enhanced tissue binding properties.
J. Biol. Chem.  285(12):9090-9 (2010)

• Caputo R, Dellagreca M, de Paola I, Mastroianni D, Longobardo L.

Novel sulfur and selenium containing bis-alpha-amino acids from 4-hydroxyproline.
Amino Acids  38(1):305-310 (2010)

• Leali D, Bianchi R, Bugatti A, Nicoli S, Mitola S, Ragona L, Tomaselli S, Gallo G, Catello S, Rivieccio V, Zetta L, Presta M

Fibroblast Growth Factor 2-antagonist Activity of a Long-Pentraxin 3-derived Antiangiogenic Pentapeptide
J Cell Mol Med. 14(8):2109-21 (2010)

• Rossi M., Piovesan P., Ghirardi O., Mastroianni D., Bombardi V., Battistini L., Cencioni M.T., Capobianco D., Borsini F., Colombo M., Verdoliva A

Immunogenic, antigenic, fibrillogenic and inflammatory properties of new simplified ß-Amyloid peptides.
Mol Immunol  46: 2524-2532 (2009)

• De Santis R, Albertoni C, Rosi A, Leoni B, Petronzelli F, D'Alessio V, Nucera E, Salvatori G, Paganelli G, Verdoliva A, Carminati P, Nuzzolo CA.

OXavidin for Tissue Targeting Biotinylated Therapeutics
J. Biomed. Biotechnol. 2009: 921434 (2009)

• Basile G, Peticca M, Cusano P, Catello S.

Yeast-secreted Recombinant Extracellular Domain of Human CD105 Antigen is Able to Bind TGF-beta Type II Receptor In Vitro.
Mol Biotechnol. 41(1):26-34 (2009)

• D’Agostino B., Bellofiore P., De Martino T., Punzo C., Rivieccio V., Verdoliva A.

Affinity purification of IgG monoclonal antibodies using the D-PAM synthetic ligand: chromatographic comparison with protein A and thermodynamic investigation of the D-PAM/IgG interaction.
J Immunol Methods 333(1-2): 126-38 (2008)

• Rossi M., Ruvo M., Marasco D., Colombo M., Cassani G., Verdoliva A.

Anti-allergic properties of a new all-D synthetic immunoglobulin-binding peptide
Mol Immunol  45 (1):226-234 (2008)

• Fantò N, Gallo G, Ciacci A, Semproni M, Vignola D, Quaglia M, Bombardi V, Mastroianni D, Zibella MP, Basile G, Sassano M, Ruggiero V, De Santis R, Carminati P.

Design, synthesis, and in vitro activity of peptidomimetic inhibitors of myeloid differentiation factor 88.
J Med Chem.  51(5):1189-202 (2008)

• Inforzato A, Rivieccio V, Morreale AP, Bastone A, Salustri A, Scarchilli L, Verdoliva A, Vincenti S, Gallo G, Chiapparino C, Pacello L, Nucera E, Serlupi-Crescenzi O, Day AJ, Bottazzi B, Mantovani A, De Santis R, Salvatori G.

Structural characterization of PTX3 disulphide bond network and its multimeric status in cumulus matrix organization.
J. Biol. Chem.  283(15):10147-61 (2008)

• Verdoliva A., Rossi M.

IgE-mediated disorders:  current therapeutics and new strategies involving synthetic peptides
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry  7 (4), 252-263 (2008)

• Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M.

Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells.
J Biol Chem.  283(31):21769-78 (2008)

• M. Cianfriglia, M. L. Dupuis, A. Molinari, A. Verdoliva, R. Costi, C. M.aria Galluzzo, M. Andreotti, A. Cara, R.Di Santo and L. Palmisano

HIV-1 Integrase Inhibitors Are Substrates for the Multidrug Transporter MDR1-P-glycoprotein
Retrovirology   4, 17-26 (2007)

• V. Rivieccio, A. Esposito, P. Bellofiore, P. Palladino, M. Sassano, M. Colombo, A. Verdoliva

High-level expression and efficient purification of recombinant human long pentraxin PTX3 in Chinese hamster ovary cells
Protein Expression and Purification 51, 49–58 (2007)

• Basile G., Peticca M., Catello S.

Site-specific biotinylation of human myeloid differentiation protein 88 in D. melanogaster Schneider
Molecular Biotechnology  35(3), 253-261 (2007)

• De Santis R, Albertoni C, Petronzelli F, Campo S, D'Alessio V, Rosi A, Anastasi AM, Lindstedt R, Caroni N, Arseni B, Chiodi P, Verdoliva A, Cassani G, Chinol M, Paganelli G, Carminati P.

Low and high tenascin-expressing tumors are efficiently targeted by ST2146 monoclonal antibody
Clin Cancer Res. 12 (7 Pt 1):2191-6 (2006)

• Camozzi M, Rusnati M, Bugatti A, Bottazzi B, Mantovani A, Bastone A, Inforzato A, Vincenti S, Bracci L, Mastroianni D, Presta M.

Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3.
J Biol Chem. 281(32):22605-13 (2006)

• P. Bellofiore, F. Petronzelli, T. De Martino, O. Minenkova, V. Bombardi, A. M. Anastasi, R. Lindstedt, F. Felici, R. De Santis, A. Verdoliva

Identification and refinement of a peptide affinity ligand with unique specificity for a monoclonal anti-tenascin-C antibody by screening of a phage display library
J Chromatogr A 1107(1-2):182-91 (2006)

• Petronzelli F., Pelliccia A., Anastasi A.M., D'Alessio V., Albertoni C., Rosi A., Leoni B., De Angelis C., Paganelli G., Palombo G., Dani M., Carminati P. e De Santis R.

Improved tumor targeting by combined use of two antitenascin antibodies
Clin Cancer Res. 11 (19 Pt 2):7137s-7145s (2005)

• Loiarro M, Sette C, Gallo G, Ciacci A, Fantò N, Mastroianni D, Carminati P, Ruggiero V.

Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-{kappa}B
J Biol Chem. 280(16):15809-14 (2005)

• A Verdoliva, D Marasco, A De Capua,  A Saporito, P Bellofiore, V Manfredi, R Fattorusso, C Pedone, M Ruvo

A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library
Chembiochem  6 (7): 1242-53 (2005)

• De Santis R, Anastasi AM, D'Alessio V, Pelliccia A, Albertoni C, Rosi A, Leoni B, Lindstedt R, Petronzelli F, Dani M, Verdoliva A, Ippolito A, Campanile N, Manfredi V, Esposito A, Cassani G, Chinol M, Paganelli G, Carminati P

Novel antitenascin antibody with increased tumour localisation for Pretargeted Antibody-Guided RadioImmunoTherapy (PAGRIT).
Br. J. Cancer. 88(7):996-1003 (2003)

• Verdoliva A, Pannone F, Rossi M, Catello S, Manfredi V.

Affinity purification of polyclonal antibodies using a new all-D synthetic peptide ligand: comparison with protein A and protein G.
J Immunol Methods 271:77-88 (2002).

• Rossi, M., Manfredi, V., Ruvo, M., Fassina, G., Verdoliva, A

Sequence-simplification and chimeric assembly: new models of peptide antigen modification.
Mol Immunol. 39:443-51 (2002).

• Marino M, Rossi M, Ruvo M, Fassina G

Novel molecular targets for systemic lupus erythematosus
Curr Drug Targets 3(3):223-8 (2002)

• Fassina, G., Ruvo, M., Palombo, G., Verdoliva, A., Marino, M.

Novel ligands for the affinity-chromatographic purification of antibodies.
J. Biochem. Biophys. Methods 49:481-90 (2001)

• De Falco, S., Rivoletto, M.G., Verdoliva, A., Ruvo, M., Rauchi, A., Marino, M., Senatore, S., Cassani, G., Alberti, A., Pontisso, P, Fassina G.

Cloning and expression of a novel hepatitis B virus-binding protein from HepG2 cells.
J Biol Chem. 276:36613-23 (2001)

• Dani M.

Peptide display libraries: design and construction.
J Recept Signal Transduct Res. 21(4):469-88 (2001)

• Dani M.

Biological libraries.
J Recept Signal Transduct Res. 21(4):447-68 (2001)

• De Falco, S., Ruvo, M., Verdoliva, A., Scarallo, A., Raimondo, D., Raucci, A.and Fassina, G.

N-terminal Myristylation of HBV preS1 domain enhances receptor recognition
J Pept Res. 57:390-400 (2001)

• Verdoliva A, Basile G, Fassina G

Affinity purification of immunoglobulins from chicken egg yolk using a new synthetic ligand.  
J Chromatogr B Biomed Sci Appl  749(2):233-42 (2000)

• Marino M, Ippolito A, Ruvo M, Scarallo A, Volpe S, Fassina G.

Prevention of experimental autoimmune encephalomyelitis by encephalitogenic epitope sequence simplified derivatives.
Mol Immunol. 37(16):951-60 (2000)

• Marino M, Ruvo M, De Falco S, Fassina G.

Prevention of systemic lupus erythematosus in MRL/lpr mice by administration of an immunoglobulin-binding peptide.
Nat Biotechnol. 18(7):735-9 (2000)

• Fassina G

Protein A mimetic (PAM) affinity chromatography. Immunoglobulins purification
Methods Mol Biol. 147:57-68 (2000)

• Monti MM, Valanzuolo S, Cassani G, Colombo M

Transgenic tomatoes expressing a cucumber mosaic virus satellite RNA: field testing and analysis of satellite RNA spread
J Plant Pathol. 81 (2):113-122 (1999)

• Marino M, Ippolito A, Fassina G.

Inhibition of experimental autoimmune encephalomyelitis in SJL mice by oral administration of retro-inverso derivative of encephalitogenic epitope P87-99.
Eur J Immunol. 29(8):2560-6 (1999)

• Palombo G, Rossi M, Cassani G, Fassina G.

Affinity purification of mouse monoclonal IgE using a protein A mimetic ligand (TG19318) immobilized on solid supports
J Mol Recognit. 11(1-6):247-9 (1998)

• Palombo G, De Falco S, Tortora M, Cassani G, Fassina G.

A synthetic ligand for IgA affinity purification
J Mol Recognit. 11(1-6):243-6 (1998)

• Guerrier L, Flayeux I, Schwarz A, Fassina G, Boschetti E.

IRIS 97: an innovative protein A-peptidomimetic solid phase medium for antibody purification
J Mol Recognit. 11(1-6):107-9 (1998)

• Fassina, G., Verdoliva, A., Palombo, G., Ruvo, M. and Cassani, G.

Immunoglobulins specificity of TG19318: a novel synthetic ligand for antibody affinity purification”.
J. Mol. Recognit. 11:128-133 (1998)

• Marino M, Corti A, Ippolito A, Cassani G, Fassina G.

Effect of bench-scale culture conditions on murine IgG heterogeneity
Biotechnol Bioeng 54(1):17-25 (1997)

• Fassina G, Verdoliva A, Odierna MR, Ruvo M, Cassani G

A protein A mimetic peptide ligand for the affinity purification of antibodies.
J. Mol. Rec. 9: 564-569 (1996)

• Merli S, De Falco S, Verdoliva A, Tortora M, Villain M, Silvi P, Cassani G, Fassina G

An expression system for the single-step production of recombinant human amidated calcitonin
Protein Expr Purif 7(4):347-54 (1996)

• Verdoliva A, Ruvo M, Cassani G, Fassina G

Topological mimicry of cross-reacting enantiomeric peptide antigens
J Biol Chem  270(51): 30422 (1995)

• Verdoliva A, Ruvo M, Villain M, Cassani G, Fassina G

Antigenicity of topochemically related peptides
Biochim Biophys Acta 1253(1):57-62 (1995)

• Verdoliva A, Cassani G, Fassina G

Affinity Purification of Polyclonal Antibodies Using Immobilized Multimeric Peptides
J Chromatogr B Biomed Appl 664(1):175-83 (1995)

• Merli S, Corti A, Cassani G.

Production of soluble tumor necrosis factor receptor type I in Escherichia coli: optimization of the refolding yields by a microtiter dilution assay
Anal Biochem. 230(1):85-91 (1995)

• Fassina G, Cassani G, Gnocchi P, Fornasiero MC, Isetta AM

Inhibition of interleukin-2/p55 receptor subunit interaction by complementary peptides
Arch Biochem Biophys. 318(1):37-45 (1995)

• Corti A, Merli S, Bagnasco L, D'Ambrosio F, Marino M, Cassani G.

Identification of two forms (31-33 and 48 kD) of the urinary soluble p55 tumor necrosis factor receptor that are differentially N- and O-glycosylated.
J Interferon Cytokine Res. 15(2):143-52 (1995).

• Radulescu RT, Bellitti MR, Ruvo M, Cassani G, Fassina G.

Binding of the LXCXE insulin motif to a hexapeptide derived from retinoblastoma protein.
Biochem Biophys Res Commun. 206(1):97-102 (1995)

• Fassina G.

Complementary peptides as recognition molecole
Agents Actions Suppl. 46:109-20 (1995)

PATENTS